Darla was born in late 16th century Britain. She emigrated to Virginia Colony in North America where she became a prostitute. She was dying of syphilis when The Master changed her into a vampire. Darla quickly became one of his favorite henchmen and he viewed her like a daughter. Over the years she killed many innocent people for fun before being intrigued by a boy named Liam. She sired him and he became the infamous Angelus. At her urging her Angelus murdered his family and everyone else in his village.